MT 196 Solution Properties of Water Soluble Tablets (ST)
Content Handbook O
Outline of method
A water-soluble tablet, or a fragment of a water soluble tablet, is dissolved in Standard water D at maximum use rate and stirred for a specified time. The solution is allowed to stand undisturbed for 2hours and then poured onto a 75 μm sieve. Any residue is collected, dried, weighed and recorded. The method is gravimetric and provides ample time for tablets to disintegrate and for the active substance to dissolve.
The method is intended for measuring the properties of solutions of water soluble tablets (ST). The test aims to ensure that water soluble tablets produce stable solutions without precipitation or flocculation.