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MT 179.1 Degree of Dissolution and Solution Stability

Content Handbook O


Outline of method

The formulation is dissolved in Standard Water in a graduated 250 ml cylinder. After 15 inversions of the test cylinder and a standing time of 5 min, the degree of dissolution is determined by pouring the content of the test cylinder through a 75 μm sieve. Any residue on the sieve is quantified. The stability of the solution is checked by allowing the filtrate to stand for a period of 24 h and filtering it again through a 75 μm sieve. Again, any residue on the sieve is quantified.



The method is intended for the determination of the degree of dissolution and the solution stability of solid, water soluble formulations.