Content Handbook K

Outline of method

The solubility - within predefined ranges - of a test substance in organic solvents is determined by adding measured volumes of solvent to a known mass of test substance until complete dissolution is observed. A preliminary test is employed to determine the approximate solubility of the test substance. The results of the preliminary test are used to select the most appropriate mass of test substance for the test.

Scope

The method is not suitable for the determination of solubilities below 10 g/l. To determine lower solubilities, or when precision higher than the predefined ranges described is required, MT157 (Water Solubility) may be adapted.