MT 198 Toluene

Content Handbook O


Outline of method

The content of toluene as relevant impurity of the active ingredient is determined at low levels by headspace capillary gas chromatography with flame ionisation or mass spectrometric detection and internal standardisation (standard addition method).



The method can be used for solid and for liquid formulated products (water- and organic solvent-based). The active ingredient does not interfere with this method. The maximum permitted concentration of toluene is dependent on the active ingredient in the formulation.