MT 197 Disintegration of Tablets

Content Handbook O


Outline of method

One entire tablet is added to a defined volume of CIPAC standard water D and mixed by gentle stirring for the specified disintegration time of the tablet. The suspension is then passed through a 2000μm sieve. The absence of a residue on the screen indicates complete disintegration of the tablet.



This method is intended for measuring the completeness of the disintegration of tablets independent of the use rate. The method is designed for, but not limited to the disintegration of effervescent tablets.